Risk Factors for Multidrug Resistant Tuberculosis among patients with pulmonary tuberculosis at Tertiary care hospital

Muhammad Yasin, Nasir Mahmood, Syed Ahmed Saeed Naqvi, Hamid Nisar Khan, Amir Suleman, Halima Sadia, Faheem Jan


Background: The incidence of multidrug-resistant tuberculosis (MDR-TB) is
very high in Pakistan considering the fact that Pakistan is one of the few countries with a high burden of tuberculosis – both drug susceptible and drug
resistant tuberculosis.

Objective: This study focused on the risk factors leading to development of
MDR-TB in patients diagnosed with tuberculosis.

Methodology: This was a case control study to evaluate the demographic,
social, and clinic behavioral risk factors for MDR-TB in patients diagnosed with
tuberculosis. Structured questionnaire and review of clinical records were
used to collect data for this study which was entered into and analyzed using
SPSS 20. Multi-variate logistic regression was used to determine independent
risk factors affecting the outcome in patients with tuberculosis. P≤ 0.05 was
taken to be significant.

Results: There were 180 study participants divided into two groups of 90 each.
Age, close quarter living, treatment with anti-tubercular drugs in the past and
diabetes mellitus were found to be independently associated with development
of multi drug resistant tuberculosis.

Conclusion: Active case finding strategies for diagnosis and management of
multi drug resistant tuberculosis should focus on younger patients, patients
who have been treated in the past for tuberculosis and those who live in overcrowded places.


Diabetes Mellitus; HIV; Retreatment; Tuberculosis

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