Risk Factors for Multidrug Resistant Tuberculosis among patients with pulmonary tuberculosis at Tertiary care hospital

Authors

  • Muhammad Yasin
  • Nasir Mahmood
  • Syed Ahmed Saeed Naqvi
  • Hamid Nisar Khan
  • Amir Suleman
  • Halima Sadia
  • Faheem Jan

Keywords:

Diabetes Mellitus, HIV, Retreatment, Tuberculosis

Abstract

Background: The incidence of multidrug-resistant tuberculosis (MDR-TB) isvery high in Pakistan considering the fact that Pakistan is one of the few countries with a high burden of tuberculosis – both drug susceptible and drugresistant tuberculosis.Objective: This study focused on the risk factors leading to development ofMDR-TB in patients diagnosed with tuberculosis.Methodology: This was a case control study to evaluate the demographic,social, and clinic behavioral risk factors for MDR-TB in patients diagnosed withtuberculosis. Structured questionnaire and review of clinical records wereused to collect data for this study which was entered into and analyzed usingSPSS 20. Multi-variate logistic regression was used to determine independentrisk factors affecting the outcome in patients with tuberculosis. P≤ 0.05 wastaken to be significant.Results: There were 180 study participants divided into two groups of 90 each.Age, close quarter living, treatment with anti-tubercular drugs in the past anddiabetes mellitus were found to be independently associated with developmentof multi drug resistant tuberculosis.Conclusion: Active case finding strategies for diagnosis and management ofmulti drug resistant tuberculosis should focus on younger patients, patientswho have been treated in the past for tuberculosis and those who live in overcrowded places.

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Published

2020-07-11

How to Cite

Yasin, M., Mahmood, N., Naqvi, S. A. S., Khan, H. N., Suleman, A., Sadia, H., & Jan, F. (2020). Risk Factors for Multidrug Resistant Tuberculosis among patients with pulmonary tuberculosis at Tertiary care hospital. Pakistan Journal of Chest Medicine, 25(4), 151–155. Retrieved from http://pjcm.net/index.php/pjcm/article/view/644

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Original Article

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