Pattern of Antimicrobial Resistance and Outcomes of Patients with Sepsis admitted to a Tertiary Care Hospital in Peshawar: A Prospective study
Keywords:
Sepsis, Antimicrobial Resistance, Outcomes, Antibiogram, AntibioticsAbstract
Background: Sepsis is a life-threatening illness induced by a change in the host's reaction to various infections. Objectives: To study the antimicrobial resistance patterns and outcomes in patients with sepsis admitted to a tertiary care hospital in Peshawar. Methodology: In this prospective study sepsis patients were followed till an outcome was assigned to them. The data was collected and independent samples t-test, chi square test and multivariate logistic regression was used to study the effect of various dependent variables on mortality using SPSS version 25. A p-value of less than 0.05 was taken as significant. Results: In 106 patients with sepsis the mean age was 44.5 years (SD=19.2 years) and 60.3% (n=64) were males. The overall mortality was 21.3% (n=23). Presence of DM (aOR: 6.1 CI:1.31-29.27.8, p-value=0.02), increasing age (aOR: 1.05, CI 1.007-1.104 p-value=0.025) and rising days of hospitalization (aOR:1.08, CI:1.003-1.16, p-value=0.041) had the strongest statistically significant relation with mortality. As compared to those admitted in the ICU, which was taken as reference, the chances of worst outcome were extremely low in those admitted to surgical unit (aOR: 0.027, CI:0.001-0.625, p-value=0.023). Hypertension (aOR:, CI:, p-value=0.74) and gender (aOR: 0.68, CI: 0.087-4.5, p-value= 0.62) had no positive correlation with mortality. Conclusion: Our result demonstrates that the growth of rare organisms like B Cepacia and multi-resistant E. coli. The creation of a local antibiogram at the institutional, provincial, and national levels can aid in the prompt administration of culture sensitive antibiotics, allowing for better management of such cases.References
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