Frequency of newly diagnosed Diabetes Mellitus in Tuberculosis Patients: A Cross-Sectional Study

Authors

  • Nazia Jehanzeb Department of Pulmonology, Ayub Medical College, Abbottabad - Pakistan
  • Mohammad Yasin Ayub Medical College Abbottabad
  • Ali Shan Health Department, Khyber Pakhtunkhwa – Pakistan
  • Usman Ghani Saidu Group of Teaching Hospitals, Swat – Pakistan
  • Sanullah Tareen FJ Institute of Chest Diseases, Quetta - Pakistan
  • Faheem Jan Common Management Unit (AIDS, TB & MALARIA), Islamabad - Pakistan

Keywords:

Tuberculosis, Diabetes Mellitus, Random Blood Sugar

Abstract

Background: Tuberculosis (TB) is one of the oldest diseases with a high mortality rate and is a serious public health problem all over the world. The disease is more common in some regions of the world, and some risk factors like overcrowding, immunocompromised states, and diabetes mellitus (DM) are well-known risk factors for its development and are also associated with delays in sputum conversion and unsuccessful outcomes.Objective: To determine the frequency of newly diagnosed diabetes mellitus (DM) in TB patients.Methodology: The present study was conducted at the Department of Pulmonology, Ayub Teaching Hospital, Abbottabad, from 2021 to 2022. Patients aged between 16-80 years, who presented with TB were enrolled in this study. TB wasdiagnosed via detection of MTB in sputum via microscopy, gene expert, or culture, or when decided by the consultant physician on the basis of a clinico-radiological basis. Newly diagnosed DM cases included those whose fasting blood sugar was >126 mg/dl or whose random blood sugar was >200 mg/dl.Results: Among study cases, 53.8% were male and 46.2% were female, with a mean age of 46.1±7.5 years. The difference in age and gender distribution was significant in TB patients. The rate of newly diagnosed DM patients was found to be 25.8%, with 11.0% among male patients and 14.8% among female patients. A positive and significant association (P = 0.03) was found among DM diagnosis in tuberculosis patients.Conclusion: The present study concluded that among tuberculosis patients, the occurrence of newly diagnosed diabetes mellitus was high, therefore, the concerned bodies are required to implement diabetes screening at TB clinics.

Author Biography

Mohammad Yasin, Ayub Medical College Abbottabad

Pulmonary diseases , tuberculosis, asthma, COPD, pleural effusion, pneumothorax, interstitial lung diseases, pneumonias

References

Gong W, Liang Y, Wu X. The current status, challenges, and future developments of new tuberculosis vaccines. Hum Vaccin Immunother. 2018;14:1697-1716.

Kang W, Yu J, Du J. The epidemiology of extrapulmonary tuberculosis in China: A large-scale multi-center observational study. PLoS One. 2020;15:e0237753.

Holden IK, Lillebaek T, Andersen PH, Bjerrum S, Wejse C, Johansen IS. Extrapulmonary Tuberculosis in Denmark From 2009 to 2014; Characteristics and Predictors for Treatment Outcome. Open Forum Infect Dis. 2019;6:ofz388.

Shaweno D, Karmakar M, Alene KA. Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review. BMC Med. 2018;16:193.

Silva DR, Muñoz-Torrico M, Duarte R. Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs. J Bras Pneumol. 2018;44:145-152.

Habib SS, Rafiq S, Jamal WZ, Ayub SM, Ferrand RA, Khan A, et al. Engagement of private healthcare providers for case finding of tuberculosis and diabetes mellitus in Pakistan. BMC Health Serv Res. 2020;20:328.

Gezahegn H, Ibrahim M, Mulat E. Diabetes Mellitus and Tuberculosis Comorbidity and Associated Factors Among Bale Zone Health Institutions, Southeast Ethiopia. Diabetes Metab Syndr Obes. 2020;13:3879-3886.

Kumar Nathella P, Babu S. Influence of diabetes mellitus on immunity to human tuberculosis. Immunology. 2017;152:13–24.

Basir MS, Habib SS, Zaidi SMA, Zaidi SMA, Khowaja S, Hussain H, et al. Operationalization of bi-directional screening for tuberculosis and diabetes in private sector healthcare clinics in Karachi, Pakistan. BMC Health Serv Res. 2019;19:147.

Foe-Essomba JR, Kenmoe S, Tchatchouang S, Ebogo-Belobo JT, Mbaga DS, Kengne-Ndé C, et al. Diabetes mellitus and tuberculosis, a systematic review and meta-analysis with sensitivity analysis for studies comparable for confounders. PLoS One. 2021;16(12):e0261246. DOI:: 10.1371/journal.pone.0261246.

Alebel A, Wondemagegn AT, Tesema C, Kibret GD, Wagnew F, Petrucka P,. Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: a systematic review and meta-analysis of observational studies. BMC Infect Dis. 2019 Mar 13;19(1):254.

Ponce-De-Leon A, Garcia-Garcia MD, Garcia-Sancho MC, Gomez-Perez FJ, Valdespino-Gomez JL, Olaiz-Fernandez G,et al. Tuberculosis and diabetes in Southern Mexico. Diabetes Care. 2004;27(7):1584–1590.

Wang Q, Han X, Ma A, Wang Y, Bygbjerg IC, Li G,et al. Screening and intervention of diabetes mellitus in patients with pulmonary tuberculosis in poverty zones in China: rationale and study design. Diabetes Research and Clinical Practice. 2011;96(3):385–391.

Workneh MH, Bjune G. A, Yimer S. A. Prevalence and associated factors of diabetes mellitus among tuberculosis patients in South-Eastern Amhara region, Ethiopia: a cross-sectional study. PLoS One. 2016;11(1).

Workneh MH, Bjune GA, Yimer SA. Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: A systematic review. PLoS One. 2017;12(4): e0175925. DOI:10.1371/journal.pone.0175925.

Azeem S, Khan U, Liaquat A. The increasing rate of diabetes in Pakistan: A silent killer. Ann Med Surg. 2022;79:103901. DOI: 10.1016/j.amsu.2022.103901.

Downloads

Published

2024-03-02

How to Cite

Jehanzeb, N. ., Yasin, M., Shan, A. ., Ghani, U. ., Tareen, S. ., & Jan, F. . (2024). Frequency of newly diagnosed Diabetes Mellitus in Tuberculosis Patients: A Cross-Sectional Study. Pakistan Journal of Chest Medicine, 30(1), 12–16. Retrieved from https://pjcm.net/index.php/pjcm/article/view/917

Issue

Section

Original Article

Most read articles by the same author(s)

1 2 > >>