Antimicrobial susceptibility pattern of Bacteria isolated from Tracheal secretions in Intensive Care Units admitted Patients of Lahore General Hospital

Muhammad Irfan Malik, Muna Malik, Aneela Chaudhary


Background: Critically ill patients of Intensive care units (ICUs) are always at greater risk for acquiring hospital associated infections with multidrug resistant, (MDR) microorganisms. One of the commonest and important nosocomial infections, which is acquired by ICUs admitted patients, who are intubated for mechanical ventilation is ventilator-associated pneumonia (VAP). The morbidity of these patients is increasing due to invasion of MDR strains of microorganisms. The etiology of these MDR superbugs may vary according to the different ICUs settings along with patient's illness and their antibacterial treatment.

Objective: To observe Antibiogram of bacteria isolated from tracheal secretions from the patients of ICUS admitted in Lahore General Hospital (LGH).

Materials and method: This is a descriptive study carried out in Lahore General Hospital, (LGH) Lahore during Jan 2017 to Dec 2017. Total 445 samples were processed for culture and sensitivity according to standard operating procedures at Microbiology laboratory of Pathology department (PGMI, Lahore. These secretions were including the admitted patients of different ICUs of LGH. Including patients having fever 38 °C, WBCs count 10,000/mm or 3 000/mm , Purulent tracheal secretions, Diffused or patchy infiltration in chest radiograph.

Results: Out of 445 samples of tracheal secretions, 365 were collected from males and 80 from females. The large numbers of samples 222/445 were collected from PINS ICUs. 370 (83%) showed positive culture growth i.e. CFU 10. 66.2% culture showed pure growth while 16.8% showed poly-microbial growth of two and three type of bacteria. The commonest bacteria were Klebsiella pneumoniae, which was isolated from tracheal secretion. The most susceptible trend was seen with combination drugs Cefeperazone- salbactam and Pipperacillin-tazobactam more than 60% of their sensitivity was observed among Gram-negative bacteria and susceptibility to Vancomycin and Linezolid was 100% among Gram-positive bacteria.

Conclusion: The present study showed trend of bacterial antimicrobial susceptibility in tracheal secretion in ICUs admitted patients of Lahore General Hospital. In order to struggle with antibiotics resistance every hospital should design a strict and applicable infection control policies, sensible use of antibiotic, education with infection control programs.


Antimicrobial susceptibility; ICUs; Klebsiella pneumonia; MDR; Tracheal secretions; VAP

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