Mustafa Kamal, Arshad Javaid


The level of early drug resistance is an epidemiological marker to evaluate the success of the TB control program in Pakistan. Despite the fact, that Primary drug resistance in TB has repeatedly been reported from numerous areas of the world including Pakistan. An evaluation of the small number of reliable reports indicates that there is an obvious fact of an increase in the prevalence of early resistance over the years. As soon as drug resistance is confirmed in a patient who has not at all received anti- TB treatment earlier, it is named as primary resistance. Acquired resistance is that which takes place as an outcome of definite prior treatment. On the other hand, the World Health Organization (WHO) and the International Union against Tuberculosis and Lung Diseases (IUATLD), in the light of negotiations in numerous intercontinental debates, have substituted the word primary resistance by the term “drug resistance among fresh cases” and acquired resistance by the name “drug resistance among earlier managed case. Nevertheless, a lot high prevalence of acquired resistance has been reported from numerous areas of the world including Pakistan. Newer drugs for tuberculosis are improbable to come up in the near upcoming and therefore the input to achievement leftovers is satisfactory case finding, without delay and accurate diagnosis and efficient management of infective patients together with cautious introduction of second-line drugs to which the patient is vulnerable.


Primary drug resistance Tuberculosis; Pakistan; India; Africa; Western countries; Current status.

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