Evaluating the diagnostic accuracy of Gene Xpert MTB/RIF in Pulmonary Tuberculosis in Kohat Division

Saeed Khan, Zia Ullah, Lala Ruhk, Muhammad Haroon, Afsheen Bashir, Halima Sadia, Maryum Ashfaq

Abstract


Background: Tuberculosis (TB) is considered to be one of the most prominent
reasons for death globally caused by a single microorganism. However with
the advancement in the field of human health, researchers have mostly
focused on the strategies to eradicate the TB but it has not been achieved yet
because of the major gaps in terms of resource-constrained settings and is
case of huge burden of the disease. This study was conducted with the
objective to find out the importance and diagnostic accuracy of Gene Xpert
MTB/RIF in Pulmonary Tuberculosis in Kohat Division.

Methodology: This is an observational study conducted to evaluate suspected
MDR-TB patients from Kohat Division. All suspected cases were referred to
Xpert Lab and then their sputum were sent to Provincial Referencing
Laboratory (PRL lab) Hayatabad Peshawar for Culture and Drug Susceptible
TB testing. Data analysis was done in SPSS 21 and MS Excel 2013 version.

Results: A total of 925 patients were included in the study consecutively. In the
total patient population, 709 (76.6%) were having a mean age from 15-44 years. Out of 925 patients, 408 (44.1%) were males and 517 (55.1%) were females. The overall sensitivity of Xpert MTB/RIF in detecting culture-positive pulmonary TB was 56.8% (519/925) and culture Negative Pulmonary TB was 43.8% (406/925).

Conclusion: The large-scale demonstration provides a robust data on the
potential for increased case finding of TB and DR-TB through routine use of a
high sensitivity molecular diagnostic test for TB and DR-TB (Xpert MTB/RIF) in
public sector medical services. Our observations may be useful in guiding the
decisions on the scale-up of Xpert MTB/RIF in high-burden settings.


Keywords


TB; MDR-TB; XpertMTB/RIF; Kohat

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