Asbestos, Mesothelioma and Lung Cancer: An opinion
Keywords:
Asbestos, Fiber, Pleura, Dust Diseases, CancerAbstract
Health risks from asbestos exposures have been evaluated taking account of data from the past, when exposures at workplaces were higher than today. The linear no-threshold model has been applied although its relevance is unproven. Presumably, releases from natural emission sources dwarf man-made contributions to the atmospheric dispersion of asbestos. Fibers are frequently found in the lungs and pleura of deceased people from the general population. Finding of fibers does not prove that a disease is caused by asbestos. It can be reasonably assumed that a targeted search for mesothelioma and other asbestos-related conditions in exposed populations resulted in an increased detection rate. Histological and immunohistochemical characteristics of malignant mesothelioma partly overlap with other cancers, which may contribute to overdiagnosis in exposed populations. The etiology and differential diagnosis of malignant pleural mesothelioma as well as differences in carcinogenicity between chrysotile and amphibole asbestos are briefly discussed here. There are motives to strangulate the use of amphiboles fuelled by interests of chrysotile producers. In the author’s opinion, current regulations applied in some countries are exceedingly restrictive and should be revised on the basis of independent research. The promising way to reliable information would be large-scale animal experiments. It can be reasonably assumed that non-application of asbestos-containing brakes, fireproofing, insulation lagging etc. would augment the damage and numbers of civil victims of conflicts, fires and traffic accidents.References
Hodgson JT, Darnton A. The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure. Ann Occup Hyg 2000;44:565-601.
Noonan CW. Environmental asbestos exposure and risk of mesothelioma. Ann Transl Med 2017;5(11):234.
Ilgren E, Van Orden DR, Lee RJ, Kamiya YM, Hoskins JA. Further studies of Bolivian crocidolite - Part IV: Fibre width, fibre drift and their relation to mesothelioma Induction: Preliminary Findings. Epidemiology Biostatistics and Public Health 2015;12:e11167-1.
Casali M, Carugno M, Cattaneo A, Consonni D, Mensi C, et al. Asbestos lung burden in necroscopic samples from the general population of Milan, Italy. Ann Occup Hyg 2015;59:909-921.
Kovalevskii EV. Hygienic evaluation of asbestoscontaining friction goods application. Med Tr Prom Ekol 2009;(7):1-6.
Bayram M, Bakan ND. Environmental exposure to asbestos: from geology to mesothelioma. Curr Opin Pulm Med 2014;20:301-307.
Calabrese EJ, Iavicoli I, Calabrese V. Hormesis: Its impact on medicine and health. Hum. Exp. Toxicol 2013;32(2):120-152.
Jargin SV. Hormesis: umbrella mechanism only for agents present in the environment. Hum Exp Toxicol 2015;34:439-441.
Jargin SV. The Overestimation of Medical Consequences of Low-Dose Exposure to Ionizing Radiation. Newcastle upon Tyne: Cambridge Scholars Publishing; 2019.
Jargin SV. Asbestos, mesothelioma and lung cancer: An update. Pak J Chest Med 2018;24(1):39-47.
Rossini M, Rizzo P, Bononi I, Clementz A, Ferrari R, Martini F, Tognon MG. New perspectives on diagnosis and therapy of malignant pleural mesothelioma. Front Oncol 2018;8:91.
Khalid SK, Akhtar S. Mesothelioma: a misdiagnosed entity in Pakistan. Pak J Chest Med 2011;17(1).
Goldberg M, Luce D. The health impact of nonoccupational exposure to asbestos: what do we know? Eur J Cancer Prev 2009;18(6):489-503.
Carbone M, Gazdar A, Butel JS. SV40 and human mesothelioma. Transl Lung Cancer Res 2020;9(Suppl 1):S47-S59.
Saludes V, Esteve M, Casas I, Ausina V, Martró E. Hepatitis C virus transmission during colonoscopy evidenced by phylogenetic analysis. J Clin Virol 2013;57:263-266.
Milishnikova VV, Loshchilov IU, Gladkova EV, Aksenova AO, Turkina LA. Endoscopic and morphological characteristics of the bronchi and lungs in asbestosis and dust-induced bronchitis in asbestos-textile industry workers. Gig Tr Prof Zabol 1990;(7):19-22.
Likhacheva EI, Iarina AL, Vagina ER, Klimina MS, Obukhova TIu, et al. Clinical features of pulmonary diseases caused by chrysotile asbestos dust. Med Tr Prom Ekol 2000;(11):30-33.
Elovskaya LT, Gurvich EB, Gladkova EV, Elfimov AI. Occupational health and health status of workers in enterprises that mine and use asbestos. Moscow: VNIIESM; 1991.
International Agency for Research on Cancer. Asbestos (chrysotile, amosite, crocidolite, tremolite, actinolite, and anthophyllite). In: Arsenic, Metals, Fibres and Dusts. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 2012;100C:219-310.
Harris EJA, Musk A, de Klerk N, Reid A, Franklin P, Brims FJH. Diagnosis of asbestos-related lung diseases. Expert Rev Respir Med 2019;13(3):241- 249.
Chen Z, Gaudino G, Pass HI, Carbone M, Yang H. Diagnostic and prognostic biomarkers for malignant mesothelioma: an update. Transl Lung Cancer Res 2017;6:259-269.
Goldberg M, Imbernon E, Rolland P, Gilg Soit Ilg A, Savès M, et al. The French national mesothelioma surveillance program. Occup Environ Med 2006;63:390-395.
Blyth KG, Murphy DJ. Progress and challenges in mesothelioma: From bench to bedside. Respir Med 2018;134:31-41.
Schillebeeckx E, van Meerbeeck JP, Lamote K. Clinical utility of diagnostic biomarkers in malignant pleural mesothelioma: a systematic review and meta-analysis. Eur Respir Rev 2021;30(162):210057.
Ho M, Bera TK, Willingham MC, Onda M, Hassan R, et al. Mesothelin expression in human lung cancer. Clin Cancer Res 2007;13(5):1571-1575.
Pantazopoulos I, Boura P, Xanthos T, Syrigos K. Effectiveness of mesothelin family proteins and osteopontin for malignant mesothelioma. Eur Respir J 2013;41(3):706-715.
Grigoriu BD, Grigoriu C, Chahine B, Gey T, Scherpereel A. Clinical utility of diagnostic markers for malignant pleural mesothelioma. Monaldi Arch Chest Dis 2009;71(1):31-38.
Ferrari L, Carugno M, Mensi C, Pesatori AC. Circulating epigenetic biomarkers in malignant pleural mesothelioma: state of the art and critical evaluation. Front Oncol 2020;10:445.
Wolff H, Vehmas T, Oksa P, Rantanen J, Vainio H. Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations. Scand J Work Environ Health 2015;41(1):5-15.
Creaney J, Dick IM, Robinson BW. Discovery of new biomarkers for malignant mesothelioma. Curr Pulmonol Rep 2015;4:15-21.
Rossi G, Davoli F, Poletti V, Cavazza A, Lococo F. When the Diagnosis of Mesothelioma Challenges Textbooks and Guidelines. J Clin Med 2021;10(11):2434.
Cersosimo F, Barbarino M, Lonardi S, Vermi W, Giordano A, Bellan C, Giurisato E. Mesothelioma malignancy and the microenvironment: molecular mechanisms. Cancers (Basel) 2021;13(22):5664.
Wagner JC, Berry G, Skidmore JW, Timbrell V. The effects of the inhalation of asbestos in rats. Br J Cancer 1974;29:252-269.
Davis JM, Beckett ST, Bolton RE, Collings P, Middleton AP. Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats. Br J Cancer 1978;37:673-688.
Hodgson JT, Darnton A. Mesothelioma risk from chrysotile. Occup Environ Med 2010;67:432.
Frank AL. Global use of asbestos - legitimate and illegitimate issues. J Occup Med Toxicol 2020;15:16.
Asgharian B, Owen TP, Kuempel ED, Jarabek AM. Dosimetry of inhaled elongate mineral particles in the respiratory tract: The impact of shape factor. Toxicol Appl Pharmacol 2018;361:27-35.
Coin PG, Roggli VL, Brody AR. Persistence of long, thin chrysotile asbestos fibers in the lungs of rats. Environ Health Perspect 1994;102:197-199.
Suzuki Y, Yuen SR. Asbestos fibers contributing to the induction of human malignant mesothelioma. Ann N Y Acad Sci 2002;982:160-176.
Currie GP, Watt SJ, Maskell NA. An overview of how asbestos exposure affects the lung. BMJ 2009;339:b3209.
Smith AH, Wright CC. Chrysotile asbestos is the main cause of pleural mesothelioma. Am J Ind Med 1996;30:252-266.
Yu CP, Asgharian B, Pinkerton KE. Intrapulmonary deposition and retention modeling of chrysotile asbestos fibers in rats. J. Aerosol Sci 1991;22:757- 763.
Ramada Rodilla JM, Calvo Cerrada B, Serra Pujadas C, Delclos GL, Benavides FG. Fiber burden and asbestos-related diseases: an umbrella review. Gac Sanit 2021; S0213-9111(21)00082-0.
Stayner LT, Dankovic DA, Lemen RA. Occupational exposure to chrysotile asbestos and cancer risk: a review of the amphibole hypothesis. Am J Public Health 1996;86:179-186.
Sebastien P, Janson X, Gaudichet A, Hirsch A, Bignon J. Asbestos retention in human respiratory tissues: comparative measurements in lung parenchyma and in parietal pleura. IARC Sci Publ 1980;(30):237-246.
Dodson RF, Williams MG Jr, Corn CJ, Brollo A, Bianchi C. Asbestos content of lung tissue, lymph nodes, and pleural plaques from former shipyard workers. Am Rev Respir Dis 1990;142:843-847.
Gibbs AR, Stephens M, Griffiths DM, Blight BJ, Pooley FD. Fibre distribution in the lungs and pleura of subjects with asbestos related diffuse pleural fibrosis. Br J Ind Med 1991;48:762-770.
Sekido Y. Molecular pathogenesis of malignant mesothelioma. Carcinogenesis 2013;34:1413-1419.
Troitskaia NA. A comparative study of cytotoxicity of dust of carbon fibers and other fibrous materials. Gig Sanit 1993;(3):28-30.
Kashanskii SV, Kogan FM, Malysheva LG, Zykova VA. Comparative evaluation of fibrogenesis and toxicity of asbestos-containing heat-proof materials. Med Tr Prom Ekol 1994;(1):17-21.
Stayner LT, Dankovic DA, Lemen RA. Asbestosrelated cancer and the amphibole hypothesis: 2. Stayner and colleagues respond. Am J Publ Health 1997;87:688.
Finkelstein MM, Meisenkothen C. Malignant mesothelioma among employees of a Connecticut factory that manufactured friction materials using chrysotile asbestos. Ann Occup Hyg 2010;54(6):692- 696.
Gaudino G, Xue J, Yang H. How asbestos and other fibers cause mesothelioma. Transl Lung Cancer Res 2020;9(Suppl 1):S39-S46.
Bernstein D, Dunnigan J, Hesterberg T, Brown R, Velasco JA, et al. Health risk of chrysotile revisited. Crit Rev Toxicol 2013;43:154-183.
Mossman BT, Lippmann M, Hesterberg TW, Kelsey KT, Barchowsky A, Bonner JC. Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos. J Toxicol Environ Health B Crit Rev 2011;14(1-4):76-121.
Hillerdal G, Henderson DW. Asbestos, asbestosis, pleural plaques and lung cancer. Scand J Work Environ Health 1997;23(2):93-103.
Suzuki Y, Yuen SR, Ashley R. Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence. Int J Hyg Environ Health 2005;208(3):201-210.
Smith AH, Wright CC. Chrysotile asbestos is the main cause of pleural mesothelioma. Am J Ind Med 1996;30(3):252-66.
Langer AM, Nolan RP. Chrysotile: its occurrence and properties as variables controlling biological effects. Ann Occup Hyg 1994;38(4):427-451.
Ilgren E, Van Orden DR, Lee RJ, Kamiya YM, Hoskins JA. Further studies of Bolivian crocido lite - Part IV: Fibre width, fibre drift and their relation to mesothelioma induction: Preliminary findings. Epidemiol Biostat Public Health 2015;12:e11167-1.
Bernstein DM. The health risk of chrysotile asbestos. Curr Opin Pulm Med 2014;20:366-370.
Marsili D, Terracini B, Santana VS, Ramos-Bonilla JP, Pasetto R, Mazzeo A, et al. Prevention of asbestos related disease in countries currently using asbestos. Int J Environ Res Public Health 2016;13(5):494.
Nielsen LS, Baelum J, Rasmussen J, Dahl S, Olsen KE, Albin M, Hansen NC, Sherson D. Occupational asbestos exposure and lung cancer—a systematic review of the literature. Arch Environ Occup Health. 2014;69(4):191-206.
Jargin SV. Radiofrequency radiation: carcinogenic and other potential risks. J Radiat Oncol 2020;9(1):81-91.
Takata A, Yamauchi H, Toya T, Aminaka M, Shinohara Y, Kohyama N, Yoshida K. Forsterite exposure causes less oxidative DNA damage and lung injury than chrysotile exposure in rats. Inhal Toxicol 2009;21(9):739-746.
Kogan FM. Modern concept of asbestos safety. Ekaterinburg: ARGO; 1995. 67. Pylev LN. The role of modifying factors in the carcinogenic effect of asbestos and asbestoscontaining dusts. Eksp Onkol 1987;9(5):14-17.
Jargin SV. Chernobyl consequences are coming. J Radiol Prot 2022;42(1).
Tossavainen A, Kotilainen M, Takahashi K, Pan G, Vanhala E. Amphibole fibres in Chinese chrysotile asbestos. Ann Occup Hyg 2001;45:145-152.
Kane AB, Hurt RH, Gao H. The asbestos-carbon nanotube analogy: An update. Toxicol Appl Pharmacol 2018;361:68-80.
Jargin SV. Hormesis and radiation safety norms: Comments for an update. Hum Exp Toxicol 2018;37(11):1233-1243.
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