Medical Conditions Associated With Multi Drug Resistance Tuberculosis And Their Effect On Outcome

Abstract

ABSTRACT Introduction: Tuberculosis is the second leading infectious cause of death worldwide. MDR TB is a form of tuberculosis in which MTB is resistant to two or more first-line agents, usually INH and rifampicin. Despite new treatment modalities, MDR-TB still has a high mortality. Many comorbidities are either responsible for the development of MDR-TB or delay the response to treatment. Objective: Aim of this study was to see medical conditions associated with multidrug resistance tuberculosis and their effect on the outcomeMethods: This was a cross-sectional study that was carried out from June 2015 to July 2019. 545patients were included in the study. Patients were checked for comorbidities and data was recorded d on Performa. Patients outcome was determined at the end of treatment in terms of treatment completed, cured died failure to treatment, lost to follow up, still undertreatment, and transfer out.Results: The mean age in our study was 38.80+ 17.05 years. Most of the patients were in the age range of 15-24 years 22.9% (N= 125), followed by 25-34 years 21.5% (N= 117). There were 52.1% (N= 284) male and 47.9% (N= 261) female. The majority of patients were non-smoker non-addict 95.4% (N= 520). Only 2.6% (N= 14) of patients was a smoker. The prevalence of various diseases was diabetes mellitus 22.4% (N= 122), Hepatitis C 4.6% (N= 25), diabetes with other complications 3.9% (N=21) and HIV 0.6% (N=3).DM was found as the strongest risk factor for mortality in our study. Fifteen patients died because of DM aloneConclusion: There are many comorbidities that affect the outcome of MDR TB. In our study diabetes was the strongest risk factor for mortality.